Article
Genetic insights into serum cathepsins as diagnostic and therapeutic targets in knee and hip osteoarthritis.
Scientific reports - 30 Jul 2024
Shao Zhiqiang, Gao Hua, Han Qinyi, Ning Eryu, Sheng Liting, Hao Yuefeng, Che Hui, Hu Dan, Wang Chengqiang
Abstract excerpt
Osteoarthritis (OA) is a chronic disease due to the deterioration of cartilage structure and function, involving the progressive degradation of the cartilage extracellular matrix. Cathepsins, lysosomal cysteine proteases, play pivotal roles in various biological and pathological processes, particularly in protein degradation. Excess cathepsins levels are reported to contribute to the development of OA. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.