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Article

HCV-related hepatocellular carcinoma: gene signatures associated with TERT promoter mutations and sex.

Journal of translational medicine - 10 Jun 2025

Bonelli Patrizia, Tornesello Anna Lucia, Tuccillo Franca Maria, Starita Noemy, Cerasuolo Andrea, Cimmino Tiziana Pecchillo, Amiranda Sara, Izzo Francesco, Ferrara Gerardo, Buonaguro Luigi, De Re Valli, Buonaguro Franco Maria, Tornesello Maria Lina

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is a rapidly progressing disease, frequently caused by hepatitis C virus (HCV) infection and a higher prevalence in males than females. Over 60% of HCCs harbour frequent activating mutations in the telomerase reverse transcriptase promoter (TERTp). However, the relationship between TERTp status, sex, and expression of specific genes remains poorly understood. METHODS: We...

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Topics

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Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40495193
DOI: 10.1186/s12967-025-06560-w
PMCID: PMC12153190

Genes

FASTK
FLVCR1
NUCKS1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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