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Article

Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity.

Clinical and molecular hepatology - 1 Apr 2025

Kim Jin Seoub, Kim Hye Seon, Tak Kwon Yong, Han Ji Won, Nam Heechul, Sung Pil Soo, Lee Sung Won, Kwon Jung Hyun, Bae Si Hyun, Choi Jong Young, Yoon Seung Kew, Jang Jeong Won

Abstract excerpt

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) exhibits significant sex disparities in incidence, yet its molecular mechanisms remain unclear. We explored the role of telomerase reverse transcriptase (TERT) genetic alterations and hepatitis B virus (HBV) integration, both known major contributors to HCC, in sex-specific risk for HBV-related HCC. METHODS: We examined 310 HBV-related HCC tissues to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39743888
DOI: 10.3350/cmh.2024.0545
PMCID: PMC12016656

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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