Article
Local ancestry inference with poorly-matched reference panels.
PLoS genetics - 1 Jul 2026
Browning Sharon R, Temple Seth D, Browning Brian L
Abstract excerpt
The original FLARE method provides computationally efficient and highly accurate local ancestry inference in cases where a closely-matched reference panel is available for each ancestry. In this work, we extend FLARE to incorporate a haplotype clustering algorithm that enables accurate local ancestry inference in scenarios where one or more ancestries do not have a closely-matched reference. This method retains...
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