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Article

Transcriptional landscape of pleural mesothelioma patients in relation to NF2 gene mutational status.

Journal of the Egyptian National Cancer Institute - 9 Jun 2025

Orozco-Castaño Carlos, Mejía-Garcia Alejandro, Tsao Hsuan Megan, Bonilla Diego A, Carvajal-Fierro Carlos, Bruges-Maya Ricardo, Combita Alba, Parra-Medina Rafael

Abstract excerpt

BACKGROUND: Pleural mesothelioma (PM) is an aggressive cancer with poor prognosis, often driven by asbestos exposure. Mutations in the NF2 gene, a key regulator of the Hippo signaling pathway, are frequently observed in PM. However, their impact on tumor biology, immune infiltration, cytokine signaling, and therapeutic response remains poorly understood. METHODS: Using data from The Cancer Genome Atlas, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40484892
DOI: 10.1186/s43046-025-00284-0
PMCID: PMC13313441

Genes

NF2
FGF2
HOXA11
MYL7
NRG1
TGFB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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