Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomics Mendelian Randomization Identifies Lactylation-Related Molecular Traits in Type 1 Diabetes.

Journal of diabetes research - 1 Jan 2026

Ding Yu, Gao Shiyang, Ying Lingwen, Tang Jie, Chang Guoying, Huang Yiguo, Yu Tingting, Li Xin, Wang Xiumin

Abstract excerpt

BACKGROUND: Lactylation is a posttranslational modification involved in cellular metabolic and immune processes. Although dysregulated lactate metabolism has been implicated in type 1 diabetes (T1D), the genetic relevance of lactylation-related molecular traits remains poorly defined. METHODS: Summary-data-based Mendelian randomization (SMR) was applied to integrate blood-derived methylation/expression/protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Multiomics

Share to Protein Processing, Post-Translational

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 42394584
DOI: 10.1155/jdr/9544974
PMCID: PMC13329454

Genes

PNKD
HMGB1
PDAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomics Mendelian Randomization Identifies Lactylation-Related Molecular Traits in Type 1 Diabetes.PMID 42394584Read ↗

Integrative multi-omics Mendelian randomization reveals key lipid metabolism genes as therapeutic targets for diabetic nephropathy pathogenesis.Semantic proximity Read ↗

A multi-omics Mendelian randomization study reveals PAM as a potential therapeutic target for type 2 diabetes.Semantic proximity Read ↗

ChIP-seq and RNA-seq Reveal the Involvement of Histone Lactylation Modification in Gestational Diabetes MellitusSemantic proximity Read ↗

Transcriptome-wide Mendelian randomization during CD4+ T cell activation reveals immune-related drug targets for cardiometabolic diseases.Semantic proximity Read ↗

The Palmitoyltransferases ZDHHC6 and ABHD17A Modulate Type 2 Diabetes Risk via Genetic Causality and Molecular InteractionsSemantic proximity Read ↗

Monocyte Immunometabolic Axis Linking Type 2 Diabetes to Coronary Artery Disease Revealed by Multi-Omics Integration and Mendelian Randomization.Semantic proximity Read ↗

Immune Cell-Based Transcriptomic Mendelian Randomization and Colocalization Study on Type 1 DiabetesSemantic proximity Read ↗

Based on systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for diabetes.Semantic proximity Read ↗

Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation studySemantic proximity Read ↗

Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications.Semantic proximity Read ↗

Genetic relations between leukocyte counts, type 1 diabetes, and coronary artery diseaseSemantic proximity Read ↗

Transcriptome analysis combined with Mendelian randomization screening for biomarkers causally associated with diabetic retinopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.