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StabLyzeGraph: High-throughput screening of combinatorial mutations using graph neural networks.

Protein science : a publication of the Protein Society - 1 Apr 2026

Waqas Muhammad, Natale Benito, Roggia Michele, Saha Prasenjit Prasad, Mileni Mauro, Cosconati Sandro

Abstract excerpt

Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc. However, achieving rapid and significant improvements has been historically challenging due to the vast mutational space and the complex...

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PMID: 41795206
DOI: 10.1002/pro.70534
PMCID: PMC12967658

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