Article
Defined lifestyle and germline factors predispose Asian populations to gastric cancer.
Science advances - 1 May 2020
Suzuki Akihiro, Katoh Hiroto, Komura Daisuke, Kakiuchi Miwako, Tagashira Amane, Yamamoto Shogo, Tatsuno Kenji, Ueda Hiroki, Nagae Genta, Fukuda Shiro, Umeda Takayoshi, Totoki Yasushi, Abe Hiroyuki, Ushiku Tetsuo, Matsuura Tetsuya, Sakai Eiji, Ohshima Takashi, Nomura Sachiyo, Seto Yasuyuki, Shibata Tatsuhiro, Rino Yasushi, Nakajima Atsushi, Fukayama Masashi, Ishikawa Shumpei, Aburatani Hiroyuki
Abstract excerpt
Germline and environmental effects on the development of gastric cancers (GC) and their ethnic differences have been poorly understood. Here, we performed genomic-scale trans-ethnic analysis of 531 GCs (319 Asian and 212 non-Asians). There was one distinct GC subclass with clear alcohol-associated mutation signature and strong Asian specificity, almost all of which were attributable to alcohol intake behavior,...
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