Article
Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.
Diabetes - 1 Dec 2017
Sobrin Lucia, Chong Yong He, Fan Qiao, Gan Alfred, Stanwyck Lynn K, Kaidonis Georgia, Craig Jamie E, Kim Jihye, Liao Wen-Ling, Huang Yu-Chuen, Lee Wen-Jane, Hung Yi-Jen, Guo Xiuqing, Hai Yang, Ipp Eli, Pollack Samuela, Hancock Heather, Price Alkes, Penman Alan, Mitchell Paul, Liew Gerald, Smith Albert V, Gudnason Vilmundur, Tan Gavin, Klein Barbara E K, Kuo Jane, Li Xiaohui, Christiansen Mark W, Psaty Bruce M, Sandow Kevin, Jensen Richard A, Klein Ronald, Cotch Mary Frances, Wang Jie Jin, Jia Yucheng, Chen Ching J, Chen Yii-Der Ida, Rotter Jerome I, Tsai Fuu-Jen, Hanis Craig L, Burdon Kathryn P, Wong Tien Yin, Cheng Ching-Yu
Abstract excerpt
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (N = 2,969 case and 4,096 control subjects) and severe DR (N = 1,277...
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