Article
Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models.
Scientific reports - 24 Sept 2020
Trabjerg Michael Sloth, Mørkholt Anne Skøttrup, Lichota Jacek, Oklinski Michal Krystian Egelund, Andersen Dennis Christian, Jønsson Katrine, Mørk Kasper, Skjønnemand Marie-Louise Nibelius, Kroese Lona John, Pritchard Colin Eliot Jason, Huijbers Ivo Johan, Gazerani Parisa, Corthals Angelique, Nieland John Dirk Vestergaard
Abstract excerpt
The etiology of CNS diseases including multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis remains elusive despite decades of research resulting in treatments with only symptomatic effects. In this study, we provide evidence that a metabolic shift from glucose to lipid is a key mechanism in neurodegeneration. We show that, by downregulating the metabolism of lipids through the key molecule...
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