Article
Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.
Cell and tissue research - 1 Jul 2018
Stojkovska Iva, Krainc Dimitri, Mazzulli Joseph R
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized pathologically by the presence of Lewy bodies comprised of insoluble alpha (α)-synuclein. Pathological, clinical and genetic studies demonstrate that mutations in the GBA1 gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase) that is deficient in Gaucher's disease, are important risk factors for the development of PD....
Topics
- Animals
- Glucosylceramidase
- Humans
- Lysosomes
- Models, Biological
- Mutation
- Parkinson Disease
- alpha-Synuclein