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Article

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG.

Investigative ophthalmology & visual science - 2 Jun 2025

Chen Jianqi, Zhuo Xiaohua, Li Yangjiani, Zhu Yingting, Li Zhidong, Shen Xinyue, Zhuo Yehong, Tan Hongmei, Lei Lei

Abstract excerpt

Purpose: Genome-wide association studies have identified numerous loci associated with POAG. However, functional insights remain limited owing to challenges from noncoding regions and complex linkage disequilibrium. We aimed to bridge these gaps in POAG by integrating genomic and multitissue transcriptomic data and identifying novel systemic regulatory genes. Methods: We analyzed POAG genomic data from FinnGen...

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Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glaucoma, Open-Angle

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Source

Open in PubMed Open full text

Identifiers

PMID: 40459497
DOI: 10.1167/iovs.66.6.7
PMCID: PMC12136138

Genes

CALCRL
GFPT1
MTMR3
AFAP1
KREMEN1
TRIOBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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