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Article

Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma.

Translational vision science & technology - 6 Apr 2026

Pan Zheng, Liu Ke, Jiang Bing, Dong Chuning

Abstract excerpt

Purpose: Primary open-angle glaucoma (POAG) is a common eye disorder that can lead to irreversible vision loss. Although genome-wide association studies (GWAS) have identified several genetic loci associated with POAG risk, the specific causative genes and mechanisms remain unclear. Methods: This study utilized the Unified Test for Molecular Signature (UTMOST) for cross-tissue analysis, along with Functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41983772
DOI: 10.1167/tvst.15.4.13
PMCID: PMC13094785

Genes

FMNL2
AFAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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