Article
Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study.
Archives of pediatrics & adolescent medicine - 1 Jun 2012
Belsky Daniel W, Moffitt Terrie E, Houts Renate, Bennett Gary G, Biddle Andrea K, Blumenthal James A, Evans James P, Harrington Honalee, Sugden Karen, Williams Benjamin, Poulton Richie, Caspi Avshalom
Abstract excerpt
OBJECTIVE: To test how genomic loci identified in genome-wide association studies influence the development of obesity. DESIGN: A 38-year prospective longitudinal study of a representative birth cohort. SETTING: The Dunedin Multidisciplinary Health and Development Study, Dunedin, New Zealand. PARTICIPANTS: One thousand thirty-seven male and female study members. MAIN EXPOSURES: We assessed genetic risk with a...
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