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Article

Energy-Dependent Changes in Ion Mobility Peak Width Reveal Stability Shifts in Ribonucleic Acid Stem Loops.

Journal of the American Society for Mass Spectrometry - 2 Jul 2025

Anders Anna G, Anthenien Jacqueline, Kilde Ingrid R, Dufrene Courteney, Koutmos Markos, Ruotolo Brandon T

Abstract excerpt

Ribonucleic acids (RNAs) are becoming increasingly important to our understanding of cellular biology and our search for new or improved biotherapeutics. However, the dynamic and polydisperse nature of RNAs creates challenges for their structural characterization. Here, we focus on RNA stem-loops (i.e., hairpins), as these are ubiquitous elements of RNA secondary structures. We leverage native ion mobility-mass...

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Identifiers

PMID: 40439673
DOI: 10.1021/jasms.5c00064
PMCID: PMC13107403

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