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Article

Time-Resolved Ultraviolet Photodissociation Mass Spectrometry Probes the Mutation-Induced Alterations in Protein Stability and Unfolding Dynamics.

Journal of the American Chemical Society - 3 Apr 2024

Luo Pan, Liu Zheyi, Lai Can, Jin Zhixiong, Wang Mengdie, Zhao Heng, Liu Yu, Zhang Weiqing, Wang Xingan, Xiao Chunlei, Yang Xueming, Wang Fangjun

Abstract excerpt

How mutations impact protein stability and structure dynamics is crucial for understanding the pathological process and rational drug design. Herein, we establish a time-resolved native mass spectrometry (TR-nMS) platform via a rapid-mixing capillary apparatus for monitoring the acid-initiated protein unfolding process. The molecular details in protein structure unfolding are further profiled by a 193 nm...

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PMID: 38507251
DOI: 10.1021/jacs.4c00316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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