Implementation of NGS and SNP microarrays in routine forensic practice: opportunities and barriers.

Abstract excerpt

Forensic DNA analysis plays a pivotal role in personal identification, kinship assessment, and criminal investigations, with Short Tandem Repeat (STR) typing via capillary electrophoresis (CE) long established as the gold standard. However, CE-based STR analysis faces notable limitations in multiplexing capacity, the interpretation of degraded or mixed samples, and the resolution of complex kinship relationships....

Topics

• Polymorphism, Single Nucleotide
• Humans
• High-Throughput Nucleotide Sequencing
• Forensic Genetics
• Oligonucleotide Array Sequence Analysis
• Microsatellite Repeats
• DNA Fingerprinting