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Forensic investigative genetic genealogy based on low-quality DNA whole genome sequencing data.

Forensic science international. Genetics - 1 Mar 2026

Lu Jingwei, Liu Jing, Li Jing, Jiang Li, Ni Meng, Zhao Wenting, Dai Lv, Zhao Chuantong, Li Caixia

Abstract excerpt

Single nucleotide polymorphism (SNP) microarray technology is widely used for data acquisition in Forensic Investigative Genetic Genealogy (FIGG), but it requires high-quality DNA. Previous studies have demonstrated that whole-genome sequencing (WGS) outperforms SNP microarray technology in genotyping forensic trace and degraded DNA, improving both SNP call rates and genotyping concordance. This study evaluates...

Topics

Humans
Polymorphism, Single Nucleotide
Whole Genome Sequencing
DNA Fingerprinting
Pedigree
Forensic Genetics
Genotype
Sequence Analysis, DNA
DNA Degradation, Necrotic
DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41475293
DOI: 10.1016/j.fsigen.2025.103417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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