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Performance of a next generation sequencing SNP assay on degraded DNA.

Forensic science international. Genetics - 1 Nov 2015

Gettings Katherine Butler, Kiesler Kevin M, Vallone Peter M

Abstract excerpt

Forensic DNA casework samples are often of insufficient quantity or quality to generate full profiles by conventional DNA typing methods. Polymerase chain reaction (PCR) amplification of short tandem repeat (STR) loci is inherently limited in samples containing degraded DNA, as the cumulative size of repeat regions, primer binding regions, and flanking sequence is necessarily larger than the PCR template....

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PMID: 26036183
DOI: 10.1016/j.fsigen.2015.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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