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Cross-tissue multicellular coordination and its rewiring in cancer

28 May 2025

Abstract excerpt

The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest1–5. However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we systematically characterized cross-tissue coordinated cellular modules in healthy tissues, uncovering their spatiotemporal dynamics and phenotypic associations, and...

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PMID: 40437094
DOI: 10.1038/s41586-025-09053-4

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