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Unveiling functional heterogeneity in breast cancer multicellular tumor spheroids through single-cell RNA-seq

29 Jul 2020

Abstract excerpt

Heterogeneity is an intrinsic characteristic of cancer. Even in isogenic tumors, cell populations exhibit differential cellular programs that overall supply malignancy and decrease treatment efficiency. In this study, we investigated the functional relationship among cell subtypes and how this interdependency can promote tumor development in a cancer cell line. To do so, we performed single-cell RNA-seq of MCF7...

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PMID: 32728097
DOI: 10.1038/s41598-020-69026-7

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