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Genetic Polymorphism of CYP2R1, CYP27A1, CYP27B1, and Vitamin D Metabolites Plasma Levels in Patients with Cardiovascular Disease: A Pilot Study.

Biomolecules - 11 May 2025

Abouzid Mohamed, Kruszyna Łukasz, Kaczmarek Dominika, Kagan Leonid, Mikulska-Sauermann Aniceta Ada, Filipowicz Dorota, Resztak Matylda, Główka Franciszek K, Karaźniewicz-Łada Marta

Abstract excerpt

The active form of vitamin D, calcitriol (1,25(OH)2D3), is produced from 25(OH)D3 via enzymes encoded by CYP2R1, CYP27A1, and CYP27B1. Polymorphisms in these genes may alter vitamin D metabolism and increase cardiovascular disease risk. This preliminary study investigated these polymorphisms in 27 patients with cardiovascular disease and 26 healthy volunteers using Polymerase Chain Reaction-Restriction Fragment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40427592
DOI: 10.3390/biom15050699
PMCID: PMC12109444

Genes

CYP27B1
CYP27A1
CYP2R1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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