Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis.

Gene - 15 Dec 2018

Duan Leizhen, Xue Zonggui, Ji Huanwen, Zhang Dongdong, Wang Yan

Abstract excerpt

BACKGROUND AND OBJECTIVE: CYP2R1 is a key gene in the vitamin D metabolic pathway. It has been suggested that CYP2R1 gene variants in European populations are associated with concentrations of 25(OH)D, a biomarker of vitamin D levels and status in peripheral blood. However, a comprehensive meta-analysis of this effect including different ethnicities has never been conducted. The objective of this meta-analysis...

Topics

Join the communities discussing this publication.

Cholestanetriol 26-Monooxygenase
Cytochrome P450 Family 2
Genetic Association Studies
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Vitamin D Deficiency

Source

Identifiers

PMID: 30120973
DOI: 10.1016/j.gene.2018.08.056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis.PMID 30120973Read ↗

Genetic Polymorphisms in Cytochrome P450 Enzymes Involved in Vitamin D Metabolism and the Vitamin D Receptor: Their Clinical RelevanceSemantic proximity Read ↗

A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation.Semantic proximity Read ↗

A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls.Semantic proximity Read ↗

CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.Semantic proximity Read ↗

Association among genetic variants in the vitamin D pathway and circulating 25-hydroxyvitamin D levels in Korean adults: results from the Korea National Health and Nutrition Examination Survey 2011-2012.Semantic proximity Read ↗

Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status.Semantic proximity Read ↗

The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic PolymorphismSemantic proximity Read ↗

Genetic influence on circulating vitamin D among Saudi ArabiansSemantic proximity Read ↗

Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults.Semantic proximity Read ↗

Genetic variants in CYP2R1, CYP24A1, and VDR modify the efficacy of vitamin D3 supplementation for increasing serum 25-hydroxyvitamin D levels in a randomized controlled trial.Semantic proximity Read ↗

Variability in response to vitamin D supplementation according to vitamin D metabolism related gene polymorphisms in healthy adults.Semantic proximity Read ↗

Genetic Variants Influencing Individual Vitamin D StatusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.