Article
Genetic variants in CYP2R1, CYP24A1, and VDR modify the efficacy of vitamin D3 supplementation for increasing serum 25-hydroxyvitamin D levels in a randomized controlled trial.
The Journal of clinical endocrinology and metabolism - 1 Oct 2014
Barry Elizabeth L, Rees Judy R, Peacock Janet L, Mott Leila A, Amos Christopher I, Bostick Roberd M, Figueiredo Jane C, Ahnen Dennis J, Bresalier Robert S, Burke Carol A, Baron John A
Abstract excerpt
CONTEXT: Adequate serum 25-hydroxyvitamin D concentrations, [25(OH)D], are required for optimal bone health, and low levels are associated with chronic diseases. OBJECTIVE: We investigated whether 41 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR, and CASR) are associated with [25(OH)D] or modify the increase in [25(OH)D] from...
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