Article
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes.
JAMA - 14 Nov 2012
Levin Gregory P, Robinson-Cohen Cassianne, de Boer Ian H, Houston Denise K, Lohman Kurt, Liu Yongmei, Kritchevsky Stephen B, Cauley Jane A, Tanaka Toshiko, Ferrucci Luigi, Bandinelli Stefania, Patel Kushang V, Hagström Emil, Michaëlsson Karl, Melhus Håkan, Wang Thomas, Wolf Myles, Psaty Bruce M, Siscovick David, Kestenbaum Bryan
Abstract excerpt
CONTEXT: Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured...
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