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Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.

Discovery medicine - 1 Nov 2024

Javid Jamsheed, Mir Rashid, Elfaki Imadeldin, Almotairi Reema, Barnawi Jameel, Algehainy Naseh A, Jalal Mohammed M, Altayar Malik A, Alanazi Mohammad A, Albalawi Salem Owaid, Bhat Tanzeela, Hussain Eram, AbuDuhier Faisel M

Abstract excerpt

BACKGROUND: Insufficient vitamin D (vit D) levels are associated with various chronic conditions such as cancers, autoimmune diseases, diabetes, and cardiovascular diseases, notably coronary artery disease (CAD). The enzyme 25-hydroxylase, cytochrome P450 2R1 (CYP2R1), catalyzes the hydroxylation of vitamin D in the liver, producing the 25-hydroxyvitamin D, which is then activated in the kidney by cytochrome P450...

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PMID: 39600283
DOI: 10.24976/Discov.Med.202436190.210

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