Article
Identification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis.
BMC medicine - 11 Jan 2023
Jin Heejin, Kim Ye An, Lee Young, Kwon Seung-Hyun, Do Ah Ra, Seo Sujin, Won Sungho, Seo Je Hyun
Abstract excerpt
BACKGROUND: The pathogenesis of diabetic kidney disease (DKD) is complex, involving metabolic and hemodynamic factors. Although DKD has been established as a heritable disorder and several genetic studies have been conducted, the identification of unique genetic variants for DKD is limited by its multiplex classification based on the phenotypes of diabetes mellitus (DM) and chronic kidney disease (CKD). Thus, we...
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