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Article

TLR7 polymorphisms are associated with COVID-19 susceptibility and severity.

Frontiers in immunology - 1 Jan 2026

Paradowska Edyta, Kania Katarzyna D, Jarych Dariusz, Mikulski Damian, Jabłonowska Elżbieta, Haręża Daria A, Wójcik-Cichy Kamila

Abstract excerpt

Objectives: SARS-CoV-2 infection causes an innate immune response that is activated through pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs). Endosomal TLR7/8 detects viral ssRNA, while TLR3 also recognizes dsRNA formed during viral replication. Both RIG-I and MDA5 recognize SARS-CoV-2 RNA in the cytoplasm of infected...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42292350
DOI: 10.3389/fimmu.2026.1837208
PMCID: PMC13253635

Genes

TLR7
TLR3
IFIH1
TLR8
TNF

Variants

rs3853839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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