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Dynamin‐related protein 1‐mediated mitochondrial fission contributes to IR ‐783‐induced apoptosis in human breast cancer cells

11 Jul 2018

Abstract excerpt

IR-783 is a kind of heptamethine cyanine dye that exhibits imaging, cancer targeting and anticancer properties. A previous study reported that its imaging and targeting properties were related to mitochondria. However, the molecular mechanism behind the anticancer activity of IR-783 has not been well demonstrated. In this study, we showed that IR-783 inhibits cell viability and induces mitochondrial apoptosis in...

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PMID: 29993201
DOI: 10.1111/jcmm.13749

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