Article
Depression genetic risk score is associated with anhedonia-related markers across units of analysis.
Translational psychiatry - 19 Sept 2019
Guffanti Guia, Kumar Poornima, Admon Roee, Treadway Michael T, Hall Mei H, Mehta Malavika, Douglas Samuel, Arulpragasam Amanda R, Pizzagalli Diego A
Abstract excerpt
Investigations of pathophysiological mechanisms implicated in vulnerability to depression have been negatively impacted by the significant heterogeneity characteristic of psychiatric syndromes. Such challenges are also reflected in numerous null findings emerging from genome-wide association studies (GWAS) of depression. Bolstered by increasing sample sizes, recent GWAS studies have identified genetics variants...
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