Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of DNA damage response signals and oxidative stress status with nivolumab efficacy in patients with Head and Neck Squamous Cell Carcinoma

23 May 2025

Abstract excerpt

BACKGROUND: Accumulating evidence suggests that deregulation of DNA damage response (DDR) network affects multiple aspects of the immune system. Herein, we tested the hypothesis that DDR-related signals, measured in peripheral blood mononuclear cells (PBMCs) from Head and Neck Squamous Cell Carcinoma (HNSCC) patients, correlate with the response to immune checkpoint inhibitors. METHODS: Oxidative stress and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Ferroptosis and cancer prognosis
Share to Head and Neck Cancer Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40410274
DOI: 10.1038/s41416-025-03032-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of DNA damage response signals and oxidative stress status with nivolumab efficacy in patients with Head and Neck Squamous Cell CarcinomaPMID 40410274Read ↗

The DNA damage response network in the treatment of head and neck squamous cell carcinomaSemantic proximity Read ↗

Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma.Semantic proximity Read ↗

A DNA damage repair associated signature for HNSCCSemantic proximity Read ↗

DNA Damage Repair Gene Mutations and Correlations with Immune Regulatory Gene Expression in PancancerSemantic proximity Read ↗

Evaluation of Alcohol, Tobacco, and HPV’s Synergistic regulation of Head and Neck Squamous Cell Carcinoma Treatment Response to PD-L1 Checkpoint Inhibitor TreatmentSemantic proximity Read ↗

Pancancer analysis of DNA damage repair gene mutations and their impact on immune regulatory gene expressionSemantic proximity Read ↗

Phase II study of nivolumab in patients with genetic alterations in DNA damage repair and response who progressed after standard treatment for metastatic solid cancers (KM-06).Semantic proximity Read ↗

DNA methylation variations of DNA damage response correlate survival and local immune status in melanomas.Semantic proximity Read ↗

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instabilitySemantic proximity Read ↗

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancerSemantic proximity Read ↗

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck CancerSemantic proximity Read ↗

HPV status and oxygen tension shape transcriptomic, inflammatory, and cell cycle responses in HNSCC treated with ionizing radiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.