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Article

Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

9 Dec 2016

Abstract excerpt

The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the...

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PMID: 27935939
DOI: 10.1371/journal.pbio.1002584

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