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Article

Deconstructing the GWAS library: next-generation GWAS.

Physiological reviews - 1 Oct 2025

Zhang Weirui, Koslowski Svenja, Benzaki Marouane, Lee Chang Jie Mick, Zhu Yike, Mak Michelle C E, Zhu Yonglin, Loong Shaun S E, Lettre Guillaume, Anene-Nzelu Chukwuemeka George, Foo Roger

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous common genetic variants associated with cardiovascular traits and diseases. These studies have increased our understanding of the genetic architecture of cardiac diseases and have facilitated the identification of genetic risk factors in patients. Furthermore, they have spurred the development of novel effective therapies by targeting the causal...

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PMID: 40408169
DOI: 10.1152/physrev.00025.2024

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