Article
Breast cancer risk in patients with polycystic ovary syndrome: a Mendelian randomization analysis.
Breast cancer research and treatment - 1 Feb 2021
Wen Yaokai, Wu Xiangrong, Peng Haoxin, Li Caichen, Jiang Yu, Su Zixuan, Liang Hengrui, Liu Jun, He Jianxing, Liang Wenhua
Abstract excerpt
PURPOSE: The association between polycystic ovary syndrome (PCOS) and breast cancer remains inconclusive. Conventional observational studies are susceptible to inverse causality and potential confounders. With a Mendelian randomization (MR) approach, we aimed to investigate the causal relationship between genetically predicted PCOS and breast cancer risk. METHODS: Our study included 11 PCOS-associated single...
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