Article
Selective removal of 7-ketocholesterol by a novel atherosclerosis therapeutic candidate reverts foam cells to a macrophage-like phenotype.
Atherosclerosis - 1 Oct 2025
Bhargava Prerna, Dinh Darren, Teramayi Fadzai, Silberg Ana, Petler Noa, Anderson Amelia M, Sadrerafi Keivan, Clemens Daniel M, O'Connor Matthew S
Abstract excerpt
BACKGROUND AND AIMS: The removal of the toxic oxidized cholesterol, 7-ketocholesterol (7KC), from cells through the administration of therapeutics has the potential to treat atherosclerosis and various other pathologies. While cholesterol is a necessary building block for homeostasis, oxidation of cholesterol can lead to the formation of toxic oxysterols with 7KC being the most prominent. 7KC is primarily formed...
Read the complete abstract on PubMedTopics
- Ketocholesterols
- Animals
- Foam Cells
- Atherosclerosis
- Phenotype
- Humans