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Article

TIAM1 drives prostatic branching phenotype and is a potential therapeutic target for benign prostatic hyperplasia.

JCI insight - 23 Jun 2025

Khedmatgozar Hamed, Dutta Sayanika, Dominguez Michael, Raju Murugananthkumar, Patel Girijesh Kumar, Latour Daniel, Johnson Melanie K, Fokar Mohamed, Warraich Irfan, Haynes Allan, Maurer Barry J, de Riese Werner, Brandi Luis, Matusik Robert J, Nandana Srinivas, Tripathi Manisha

Abstract excerpt

Benign prostatic hyperplasia (BPH) is the most common urologic condition in elderly men, characterized by the reactivation of developmental programs such as prostatic budding and branching. However, the molecular mechanisms underlying this reactivation in BPH remain unclear. In this study, we identified T-lymphoma invasion and metastasis-inducing protein-1 (TIAM1) as a critical regulator of prostatic budding and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40392613
DOI: 10.1172/jci.insight.188062
PMCID: PMC12220968

Genes

TIAM1
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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