Article

TIAM1 signaling drives prostatic budding and branching phenotypes and is a potential therapeutic target for BPH

2024-02-05

Abstract excerpt

Benign prostatic hyperplasia (BPH) is the most prevalent urologic disease in men aged over 50 years. However, the molecular mechanisms that drive BPH pathophysiology remain elusive. In this study, we integrated bioinformatic and experimental analyses of human BPH to identify TIAM1-RAC1 signaling pathway as a promising candidate for a molecular-based approach for BPH therapy. First, elevated TIAM1 expression in a B...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45638071-756a-5657-abe3-9a3d03dc89ec
DOI: 10.1101/2024.02.02.578055

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TIAM1 signaling drives prostatic budding and branching phenotypes and is a potential therapeutic target for BPHDOI 10.1101/2024.02.02.578055Read

TIAM1 drives prostatic branching phenotype and is a potential therapeutic target for benign prostatic hyperplasia.Semantic proximity Read

A transition zone enriched <i>WIF1</i> ⁺ basal cell subtype is associated with benign prostatic hyperplasiaSemantic proximity Read

Prostatic cancers: understanding their molecular pathology and the 2016 WHO classificationSemantic proximity Read

Integrative genomic, transcriptomic, and epigenomic analyses of benign prostatic hyperplasia reveal new options for therapySemantic proximity Read

Genomic analysis of benign prostatic hyperplasia implicates cellular relandscaping in disease pathogenesisSemantic proximity Read

Targeting phenotypic heterogeneity in benign prostatic hyperplasia.Semantic proximity Read

A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study.Semantic proximity Read

RNA sequencing and integrative analysis reveal pathways and hub genes associated with TGFβ1 stimulation on prostatic stromal cellsSemantic proximity Read

Epithelial-mesenchymal transition in prostatic disease.Semantic proximity Read

SLC25A37 is casually associated with the increased incidence of benign prostatic hyperplasiaSemantic proximity Read

Identification of a basal stem cell subpopulation in the prostate via functional, lineage tracing and single-cell RNA-seq analysesSemantic proximity Read

Single cell transcriptional profiling of benign prostatic hyperplasia reveals a progenitor-like luminal epithelial cell state within an inflammatory microenvironmentSemantic proximity Read