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Article

Advances in pathogenesis research and challenges in treatment development for acute myeloid leukemia.

International journal of hematology - 1 Oct 2024

Yamaguchi Hiroki

Abstract excerpt

Acute myeloid leukemia (AML) develops when hematopoietic stem cells acquire chromosomal and genetic abnormalities, transforming into leukemia stem cells (LSCs) and further gaining driver mutations. Advances in genomic analysis have identified numerous new gene mutations involved in AML development. Recent research has shown that individuals with germline mutations in genes like DDX41 and CEBPA develop AML upon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39225969
DOI: 10.1007/s12185-024-03837-6

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