Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytologic, histologic, and clinical correlation of minor mutations in pancreatic cysts.

Cancer cytopathology - 1 Feb 2025

Kwan Melanie C, Pitman Martha B, Zhang M Lisa

Abstract excerpt

BACKGROUND: Major mutations (e.g., KRAS, GNAS, TP53, SMAD4) in pancreatic cyst fluid (PCF) are useful for classifying and risk stratifying certain cyst types, particularly in cases with nondiagnostic cytology. However, the significance of uncommon minor mutations in PCF has yet to be reported. METHODS: In total, 127 PCF specimens (2014-2021) from 121 patients that underwent molecular analysis were identified, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytodiagnosis

Share to RNF43 gene

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Share to Pancreatic Neoplasms

Source

Identifiers

PMID: 39865498
DOI: 10.1002/cncy.22935

Genes

KRAS
ARID1A
GNAS
STK11
SMAD4
TP53
APC
ATM
BRAF
CDH1
CDKN2A
MEN1
NRAS
PIK3CA
RNF43
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytologic, histologic, and clinical correlation of minor mutations in pancreatic cysts.PMID 39865498Read ↗

Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts.Semantic proximity Read ↗

Simple mucinous cysts of the pancreas have heterogeneous somatic mutations.Semantic proximity Read ↗

Molecular Genetics of Pancreatic Neoplasms and Their Morphologic CorrelatesSemantic proximity Read ↗

Cytology and KRAS/GNAS Molecular Testing of Pancreatic Cyst Fluid for Risk Stratification of Intraductal Papillary Mucinous Neoplasms: a Single-Center Study with Histological CorrelationSemantic proximity Read ↗

Genomic alterations in pancreatic cystic neoplasms: from molecular characterization to precision clinical managementSemantic proximity Read ↗

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.Semantic proximity Read ↗

Clinical utility of incorporating next-generation sequencing results in the management algorithm of pancreatic cysts.Semantic proximity Read ↗

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas.Semantic proximity Read ↗

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia.Semantic proximity Read ↗

Characterizing Biological Behavior Beyond Morphologic Features: Next-Generation Sequencing Analysis of Large vs Small Pancreatic Cystic Lesions in a Large Multicenter Cohort of Patients.Semantic proximity Read ↗

Genomic Characterization of Low- and High-Grade Pancreatic Mucinous Cystic Neoplasms Reveals Recurrent KRAS Alterations in "High-Risk" Lesions.Semantic proximity Read ↗

Biomarkers in cystic lesions of the pancreas: Controversies and advances.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.