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Article

NSD1 mutation status determines metabolic inhibitor sensitivity in head and neck squamous cell carcinomas by regulating mitochondrial respiration.

The Journal of pathology - 1 Jul 2025

Tang Shouyi, Wang Qing, Wang Zhen, Cai Luyao, Pan Dan, Li Jing, Chen Qianming, Zhou Yu, Shen Ying-Qiang

Abstract excerpt

Head and neck squamous cell carcinomas (HNSCCs) are the most common malignant tumors in the head and neck region, characterized by a high recurrence rate and early metastasis. Despite advances in treatment, patient outcomes and prognosis remain poor, highlighting the urgent need for new therapeutic strategies. Recent research has increasingly focused on targeting glucose metabolism as a therapeutic strategy for...

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Topics

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Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycolysis

Share to Head and Neck Neoplasms

Share to Histone-Lysine N-Methyltransferase

Share to Mitochondria

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 40371884
DOI: 10.1002/path.6430

Genes

NSD1
PPARGC1A
TGFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 27 Oct 2026.

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