The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.

doi:10.1038/ncomms15503

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Article

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.

Nature communications - 26 May 2017

Goodwin Justin, Neugent Michael L, Lee Shin Yup, Choe Joshua H, Choi Hyunsung, Jenkins Dana M R, Ruthenborg Robin J, Robinson Maddox W, Jeong Ji Yun, Wake Masaki, Abe Hajime, Takeda Norihiko, Endo Hiroko, Inoue Masahiro, Xuan Zhenyu, Yoo Hyuntae, Chen Min, Ahn Jung-Mo, Minna John D, Helke Kristi L, Singh Pankaj K, Shackelford David B, Kim Jung-Whan

Abstract excerpt

Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic signatures specific to individual NSCLC subtypes remain unknown. Here, we perform an integrative analysis of human NSCLC tumour samples, patient-derived xenografts, murine model of NSCLC, NSCLC...

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Identifiers

PMID: 28548087
DOI: 10.1038/ncomms15503
PMCID: PMC5458561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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