Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.

doi:10.1126/sciimmunol.abc2691

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Article

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.

Science immunology - 11 Dec 2020

Hait Alon Schneider, Olagnier David, Sancho-Shimizu Vanessa, Skipper Kristian Alsbjerg, Helleberg Marie, Larsen Simon Muller, Bodda Chiranjeevi, Moldovan Liviu Ionut, Ren Fanghui, Brinck Andersen Nanna-Sophie, Thomsen Michelle M, Freytag Mette Ratzer, Darmalinggam Sathya, Parkes Isobel, Kadekar Darshana D, Rahbek Stine Hess, van der Horst Demi, Kristensen Lasse Sommer, Eriksson Kristina, Kjems Jørgen, Mostowy Serge, Christiansen Mette, Mikkelsen Jacob Giehm, Brandt Christian Thomas, Paludan Søren R, Mogensen Trine H

Abstract excerpt

Recurrent herpesvirus infections can manifest in different forms of disease, including cold sores, genital herpes, and encephalitis. There is an incomplete understanding of the genetic and immunological factors conferring susceptibility to recurrent herpes simplex virus 2 (HSV2) infection in the central nervous system (CNS). Here, we describe two adult patients with recurrent HSV2 lymphocytic Mollaret's...

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PMID: 33310865
DOI: 10.1126/sciimmunol.abc2691
PMCID: PMC7611067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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