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Article

Increased prevalence of coronary heart disease among current smokers carrying APOL1 risk variants within the African American population.

Journal of clinical lipidology - 1 Jan 2025

Mustra Rakic Jelena, Pullinger Clive R, Van Blarigan Erin L, Movsesyan Irina, Stock Eveline Oestreicher, Malloy Mary J, Kane John P

Abstract excerpt

BACKGROUND: The apolipoprotein L1 (APOL1) G1 and G2 gene variants, highly prevalent among the African American population (rare in other racial groups), are linked to increased risk of kidney disease, sepsis, and potentially coronary heart disease (CHD). Their role in tobacco-related CHD remains unclear. OBJECTIVE: To investigate the effect of APOL1 risk variants on the association between tobacco smoking and...

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Source

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Identifiers

PMID: 40360375
DOI: 10.1016/j.jacl.2025.04.189
PMCID: PMC12922773

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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