Article
The impact of genetic variations in retinoid X receptor alpha on the risk and prognosis of HPV-negative oral carcinoma.
European journal of oral sciences - 1 Jun 2025
Pandzic Dragan, Supic Gordana, Misic Debora, Curcin Aleksandra Petkovic, Jovic Sasa, Brkic Marko, Kozomara Zoran, Djurdjevic Katarina, Stosic Srboljub, Kozomara Ruzica
Abstract excerpt
Oral squamous cell carcinoma (OSCC) is characterized by a high recurrence rate and poor survival. The retinoid X receptor (RXR) is a nuclear receptor that modulates a variety of biological processes related to cancer, including apoptosis, cellular adhesion, and immune function. A number of cancers exhibit aberrant expression and altered function of the RXR isoform alpha (RXRA), but the polymorphisms in the RXRA...
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