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Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m 6 A modification in triple-negative breast cancer

9 May 2025

Abstract excerpt

Dysregulation of deubiquitination is essential for cancer growth. However, the role of 26 S proteasome non-ATPase regulatory subunit 14 (PSMD14) in the progression of triple-negative breast cancer (TNBC) remains to be determined. Gain- and loss-of-function experiments showed that silencing PSMD14 notably attenuated the growth, invasion, and metastasis of TNBC cells in vitro and in vivo. Overexpression of PSMD14...

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PMID: 40344056
DOI: 10.1126/sciadv.adr3173

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