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Article

ProgModule: A novel computational framework to identify mutation driver modules for predicting cancer prognosis and immunotherapy response.

Journal of translational medicine - 8 May 2025

Li Xiangmei, Pan Bingyue, Zhao Xilong, Su Yinchun, Lai Jiyin, Li Siyuan, He Yalan, Wu Jiashuo, Han Junwei

Abstract excerpt

BACKGROUND: Cancer originates from dysregulated cell proliferation driven by driver gene mutations. Despite numerous algorithms developed to identify genomic mutational signatures, they often suffer from high computational complexity and limited clinical applicability. METHODS: Here, we presented ProgModule, an advanced computational framework designed to identify mutation driver modules for cancer prognosis and...

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Topics

Humans
Immunotherapy
Neoplasms
Mutation
Prognosis
Computational Biology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Algorithms

Treatment Outcome

Source

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Identifiers

PMID: 40340863
DOI: 10.1186/s12967-025-06497-0
PMCID: PMC12063272

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