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PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals.

Emerging microbes & infections - 1 Dec 2021

Zhang Xinghai, Li Yuanguo, Jin Song, Zhang Yiming, Sun Leiyun, Hu Xinyu, Zhao Menglin, Li Fangxu, Wang Tiecheng, Sun Weiyang, Feng Na, Wang Hongmei, He Hongbin, Zhao Yongkun, Yang Songtao, Xia Xianzhu, Gao Yuwei

Abstract excerpt

Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily from migratory ducks) and Charadriiformes (primarily from shorebirds). However, little attention has been given to the transmission ability of H3N8 avian influenza viruses among mammals. Here, we study the potential human health threat and the molecular basis of mammalian transmissibility of H3N8 avian...

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Identifiers

PMID: 33840358
DOI: 10.1080/22221751.2021.1912644
PMCID: PMC8183522

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