Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management

Abstract excerpt

Abstract Disease Overview Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms, with an inherent risk for leukemic transformation (~15% over 3–5 years). Diagnosis Diagnosis is based on the presence of sustained (>3 months) peripheral blood monocytosis (≥1 × 10 9 /L; monocytes ≥10%), usually...

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