Metabolic Characteristics and Cytokine Gene Polymorphisms as Potential Risk Factors for a Higher Liver Fibrosis Stage in MASLD Patients: A Hospital-Based Study.

doi:10.3390/ijms26083730

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Article

Metabolic Characteristics and Cytokine Gene Polymorphisms as Potential Risk Factors for a Higher Liver Fibrosis Stage in MASLD Patients: A Hospital-Based Study.

International journal of molecular sciences - 15 Apr 2025

Iancu Mihaela, Coste Sorina-Cezara, Cozma Angela, Orășan Olga Hilda, Lucaciu Roxana Liana, Hangan Adriana Corina, Para Ioana, Gog Bogdan Sidonia, Procopciuc Lucia-Maria

Abstract excerpt

Polymorphisms in the Toll-like receptor 4 (TLR4) and IL-17 cytokine genes play a role in liver fibrosis progression among patients with MASLD. The current study aimed to investigate whether the IL17 (A7448G and G197A) and TLR4 (Asp299Gly and Thr399Ile) gene polymorphisms are associated with increased liver fibrosis stages in MASLD patients. Genotyping for the IL17F-A7488G, IL17A-G197A, TLR4-Asp299Gly, and...

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Topics

Humans
Liver Cirrhosis
Male
Female
Middle Aged
Interleukin-17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Toll-Like Receptor 4

Risk Factors

Genetic Predisposition to Disease

Adult

Genotype

Case-Control Studies

Aged

Cytokines

Source

Open in PubMed Open full text

Identifiers

PMID: 40332363
DOI: 10.3390/ijms26083730
PMCID: PMC12027573

Genes

IL17A
TLR4
IL17F

Variants

Provenance

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