Article
The PNPLA3 rs738409 GG genotype is associated with poorer prognosis in 239 patients with autoimmune hepatitis.
Alimentary pharmacology & therapeutics - 1 Jun 2020
Mederacke Young-Seon, Kirstein Martha M, Großhennig Anika, Marhenke Silke, Metzler Frauke, Manns Michael P, Vogel Arndt, Mederacke Ingmar
Abstract excerpt
BACKGROUND: Fibrosis progression in autoimmune hepatitis can be attenuated by immunosuppressive treatment; however, some patients progress despite therapy. Single nucleotide polymorphisms (SNPs) such as PNPLA3-rs738409, TM6SF2-rs58542926 and MBOAT7-rs641738 are associated with non-alcoholic fatty liver disease and fibrosis progression, whereas a splice variant in HSD17B13-rs72613567:TA has been shown to be...
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